中文名 | Hoechst 33258 |
英文名 | bisBenzimide H 33258 H 33258 |
别名 | 赫斯特荧光染料 33258(游离) 4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯酚 |
英文别名 | HOECHST 33258 Hoechst 33258 BISBENZIMIDE H 33258 bisBenzimide H 33258 H 33258 hoechst 33258 (bisbenzimide) CELLSTAIN- HOECHST 33258 SOLUTION BISBENZIMIDE TRIHYDROCHLORIDE HYDRATE bisbenzimide trihydrochloride cell*culture tested 4-(5-(4-METHYL-1-PIPERAZINYL)(2,5''-BI-1H-BENZIMIDAZOL)2''-YL)PHENOL p-(5-(5-(4-methylpiperazin-1-yl)benzimidazol-2-yl)benzimidazol-2-yl)phenol 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE HYDRATE |
CAS | 23491-44-3 |
EINECS | 245-689-0 |
化学式 | C25H24N6O |
分子量 | 424.5 |
密度 | 1.355±0.06 g/cm3(Predicted) |
熔点 | 314 °C |
沸点 | 746.9±70.0 °C(Predicted) |
溶解度 | H2O: 10 mg/mL |
酸度系数 | 9.23±0.15(Predicted) |
存储条件 | −20°C |
稳定性 | 稳定。与强氧化剂不相容。光敏感。 |
外观 | 粉末 |
体外研究 | Hoechst 33258, a fluorescent compound with a head-to-tail bis-benzimidazole structure, is initially found to be cytotoxic against L1210 murine leukemia. Hoechst 33258 is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), Human promyelocytic leukemia cell (HL60) and U937 cell Line. The IC 50 determined in the case of HeLa, HL60 and U937 is 51.31±4.56, 32.43±3.27 and 15.42±2.16 μM for Hoechst 33258, respectively. The cytotoxic property of Hoechst 33258 is investigated on a panel of seven tumour cell lines of different histological origin and Madine-Darby canine kidney (MDCK) normal cells. All cell lines, except MCF-7, exposed to Hoechst 33258 exhibit GI 50 from 84×10 -6 to 191.5×10 -6 mol/dm 3 . Under the same experimental conditions, Hoechst 33258, used as a binder reference compound, stops the cell cycle in S phase and G0/G1. |
危险品标志 | Xn - 有害物品 |
风险术语 | R22 - 吞食有害。 R36/38 - 刺激眼睛和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
RTECS | SM1140500 |
FLUKA BRAND F CODES | 3-8-10 |
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